Scientific study: elimination of dietary gluten does not reduce titers of type 1 diabetes-associated autoantibodies in high-risk subjects
- The study included seven patients without celiac disease who were first-degree relatives of patients with type 1 diabetes and who demonstrated a specific antibody marker associated with diabetes, but were not yet clinically diabetic.
- These patients followed a gluten-free diet for 12 months, then had gluten reintroduced into their diets for an additional 12 months.
- Results found that the diabetes-specific antibodies did not change during the gluten‑free diet or after reintroducing gluten.
- The authors concluded, “The findings do not support the hypothesis that gluten is a driving antigen in type 1 diabetes.”
While removing gluten from the diet in patients with celiac disease can reduce the frequency of occurrence of type 1 diabetes in patients with celiac disease, gluten may not have a role in inducing diabetes in non-diabetic and non-celiac disease patients.
Sources:Hummel M, et al. Elimination of Dietary Gluten Does Not Reduce Titers of Type 1 Diabetes–Associated Autoantibodies in High-Risk Subjects. Diabetes Care 25:1111–1116, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12087006