Scientific study: new markers of disease activity in celiac disease
- Researchers investigated two new markers available through blood tests, referred to as phosphorylated signal transducers and activators of transcription (pSTAT1) and T-bet, a key transcription factor for the development of T-helper type cells, to determine whether they provide value in tracking the celiac disease and the effects of gluten-free diets.
- Based on results from the study, the authors concluded, “…pSTAT1 and T-bet protein expression in peripheral blood mononuclear cells could be useful and sensible markers in the follow-up of CD patients to evaluate disease activity and response to dietary treatment.”
Biomarkers such as T-bet and pSTAT1, which can be evaluated through blood tests, may provide a simpler way to track the clinical course of celiac disease and the effects of gluten-free diets. Further research can confirm the utility of these and other blood-based biomarkers.
Frisullo G, et al. T-bet and pSTAT-1 expression in PBMC from coeliac disease patients: new markers of disease activity. Clin Exper Immunol 2009; 158:106-114.