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Scientific study: serological tests in gluten sensitivity

September 2012 | 3 min read

As more is learned about disorders related to gluten sensitivities, allergies and autoimmune reactions, additional information is needed to explain similarities and differences among these disorders and further identify markers that help diagnose and differentiate the conditions. This study sought to characterize markers of gluten sensitivity and to compare it with that found in celiac disease. 

Key Points

  • Blood samples were collected from 78 patients with gluten sensitivity and 80 patients with celiac disease and were tested for a variety of immune and antibody markers.
  • Results suggested certain key markers known to be associated with celiac disease are not found in patients with gluten sensitivity.
  • Other immune markers were noted in some patients with gluten sensitivity, but not in proportions of patients large enough to be considered both sensitive and specific.

Key Takeaways

Further research is needed to establish definitive markers for gluten sensitivity. Absence of known markers for celiac disease can assist in diagnosis of gluten sensitivity, along with presence of clinical symptoms that may include both intestinal and extra-intestinal symptoms.


Volta U, et al. Serological tests in gluten sensitivity (nonceliac gluten intolerance). J Clin Gastroenterol, 2012; 46(8):680-685.